Resource Centre

The following resources are designed to support education and learning for healthcare professionals.

Multimedia resources

For multimedia resources you will have the option at the end of each video to submit your details which will allow Nordic Pharma Ltd. to send you a personalised certificate for your continued professional development.


Please click here to listen to Professor Jan van der Linden talk about Aprotinin in patients on dual antiplatelet inhibitors undergoing acute CABG


Please click here to watch the Aprotinin Mechanism of Action video


Please click here to watch the Aprotinin Admin Video


Please click here to listen to Consultant Cardiothoracic Surgeon Mr Dumbor Ngaage share a clinical case where Aprotinin was used for salvage coronary artery bypass surgery


Please click here to listen to Consultant Cardiothoracic Anaesthetist Dr Aamer Ahmed talk about patient blood management in cardiac surgery

Clinical resources

Please find below a list of supporting clinical references. Where available links to the full paper are supplied.

Accurate costs of blood transfusion: a microcosting of administering blood products in the United Kingdom National Health Service

Stokes, E.A., Wordsworth, S.A., Staves, J. et al.


EU Regulatory assessment report: Antifibrinolytics containing aprotinin, aminocaproic acid and tranexamic acid

The Committee for Medicinal Products for Human Use (CHMP)

Increased perioperative mortality following aprotinin withdrawal: a real-world analysis of blood management strategies in adult cardiac surgery

Walkden, G.J., Verheyden, V., Goudie, R. et al. Intensive Care Med. 2013; 39:1808–1817

Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery

Myles, P.S., Smith, J.A,, Forbes, A. et al. N Engl J Med. 2017; 376:136–148

Aprotinin Decreases Postoperative Bleeding and Number of Transfusions in Patients on Clopidogrel Undergoing Coronary Artery Bypass Graft Surgery: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

Van der Linden,J., Lindvall,G., Sartipy, U. Circulation. 2005; 112 (9 Suppl): I276-80

Aprotinin for Primary Coronary Artery Bypass Grafting: A Multicenter Trial of Three Dose Regimens

Lemmer, J.H., Dilling, E.W., Morton, J.R., et al. Ann Thorac Surg. 1996; 62, 6:1659-1667

Aprotinin vs. tranexamic acid in isolated coronary artery bypass surgery

Deloge, E., Amour, J., Provenchère, S. et al. Eur J Anaesthesiol 2017;34:1–8

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