Resource Centre • Aprotinin

Resource Centre

The following resources are designed to support education and learning for healthcare professionals.

Multimedia resources Clinical resources

Multimedia resources

For multimedia resources you will have the option at the end of each video to submit your details which will allow Nordic Pharma Ltd. to send you a personalised certificate for your continued professional development.

Click here to watch as Professor Cholley provides an overview of the aprotinin administration process

Click here to watch Professor Cholley describe a case study where aprotinin was used on a high-risk patient

Click here to access a case study on "Why Choose Aprotinin?" by Mr S. Papaspyros

Click here to access a review on "How and when......isolated CABG", by Mr Dumbor Ngaage

Please click here to access an article by Professor Mahmoud Loubani reviewing the place for aprotinin in iCABG

Please click here to listen to Professor Jan van der Linden talk about Aprotinin in patients on dual antiplatelet inhibitors undergoing acute CABG

Please click here to watch the Aprotinin Mechanism of Action video

Please click here to watch the Aprotinin Admin Video

Please click here to listen to Consultant Cardiothoracic Surgeon Mr Dumbor Ngaage share a clinical case where Aprotinin was used for salvage coronary artery bypass surgery

Please click here to listen to Consultant Cardiothoracic Anaesthetist Dr Aamer Ahmed talk about patient blood management in cardiac surgery

Clinical resources

Please find below a list of supporting clinical references. Where available links to the full paper are supplied.

Accurate costs of blood transfusion: a microcosting of administering blood products in the United Kingdom National Health Service

Stokes, E.A., Wordsworth, S.A., Staves, J. et al. Transfusion. 2018; 58(4):846-853

EU Regulatory assessment report: Antifibrinolytics containing aprotinin, aminocaproic acid and tranexamic acid

The Committee for Medicinal Products for Human Use (CHMP)

Increased perioperative mortality following aprotinin withdrawal: a real-world analysis of blood management strategies in adult cardiac surgery

Walkden, G.J., Verheyden, V., Goudie, R. et al. Intensive Care Med. 2013; 39:1808–1817

Tranexamic acid in patients undergoing coronary-artery surgery

Myles, P.S., Smith, J.A,, Forbes, A. et al. N Engl J Med. 2017; 376:136–148

Aprotinin decreases postoperative bleeding and number of transfusions in patients on clopidogrel undergoing coronary artery bypass graft surgery: A double-blind, placebo-controlled, randomized clinical trial

Van der Linden,J., Lindvall,G., Sartipy, U. Circulation. 2005; 112 (9 Suppl): I276-80

Aprotinin vs. tranexamic acid in isolated coronary artery bypass surgery: A multicentre observational study

Deloge, E., Amour, J., Provenchère, S. et al. Eur J Anaesthesiol 34(5):280-287

Aprotinin: is it time to reconsider?

European Society of Anaesthesiology task force reports on place of aprotinin in clinical anaesthesia.Eur J Anaesthesiol. 32(9):591-5

2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery

Boer C,. Meesters M., Milojevic M. et al. J Cardiothor Vasc Anesth. 2018; 32(1):88-120